Epileptic Seizures

Initiation and Propagation

Epilepsy is a group of neurological disorders characterized by the repetition of seizures. Epileptic seizures are brief episodes during which the activity of large neuronal populations is excessively synchronized. However, the mechanisms that trigger this sudden synchronization are unknown. We are interested in addressing this question in models of focal epilepsy by using functional imaging, whole cell recordings and optogenetic manipulations in awake mice.